Yes, "Guardians of the Galaxy Vol. 2" is the sequel to the original "Guardians of the Galaxy" film. It was released on May 5, 2017, and continues the adventures of the Guardians as they explore Peter Quill's heritage and face new challenges. The film features the return of the beloved characters, along with new ones, and showcases themes of family and identity. It was well-received by both audiences and critics, further expanding the Marvel Cinematic Universe.

As of October 2023, "Guardians of the Galaxy Vol. 3" is considered a hit. Released in May 2023, the film received positive reviews from both critics and audiences, praising its emotional depth, character development, and humor. It performed well at the box office, grossing over $845 million worldwide, making it one of the highest-grossing films of the year. The film's success reaffirmed the popularity of the Guardians franchise within the Marvel Cinematic Universe.

Miley Cyrus did not appear in "Guardians of the Galaxy Vol. 2." However, she voiced the character Mainframe in "Guardians of the Galaxy Vol. 3." Mainframe is an artificial intelligence that has a brief but notable role in the film. The character is part of the larger Marvel universe, contributing to the film's themes of teamwork and resilience.

Thanos does not appear in "Guardians of the Galaxy Vol. 2" in a significant role. While he is mentioned and his influence is felt, the film primarily focuses on the Guardians' adventures and the development of Peter Quill's relationship with his father, Ego the Living Planet. Thanos is more prominently featured in other Marvel Cinematic Universe films, particularly in "Avengers: Infinity War" and "Avengers: Endgame."