Born in Wichita, Kansas, she gained fame in the 1980s and 1990s. She began her career in television before breaking into film. She garnered widespread recognition for her role in the TV sitcom "Cheers," earning an Emmy and a Golden Globe. Her film credits include the "Look Who's Talking" series and "Star Trek II: The Wrath of Khan." Known for her comedic talent and distinctive voice, she also participated in reality TV and advocacy work. Her career spanned multiple decades, leaving a lasting impact on Hollywood.