In "Dumb and Dumberer: When Harry Met Lloyd," the story is set in high school, where Harry Dunne and Lloyd Christmas first meet. They are both socially awkward and outcasts at their school. Their initial encounter happens when Lloyd, the new kid, inadvertently causes chaos in the school, leading to a series of humorous events. Despite their differences, they bond over their shared experiences and misadventures, forming the foundation of their iconic friendship. The film serves as a prequel to the original "Dumb and Dumber."

"When Harry Met Lloyd: Dumb and Dumberer" is a prequel to the original "Dumb and Dumber," exploring the backstory of the iconic characters Harry Dunne and Lloyd Christmas during their high school years. The film focuses on their misadventures and the development of their friendship, which ultimately leads to the events of the original film. While it features new characters and a different setting, it maintains the comedic tone and slapstick humor characteristic of the original, connecting the two films through the characters' personalities and antics.