In the movie "Splice," Dren, a genetically engineered humanoid creature, exhibits increasingly unpredictable and aggressive behavior. After developing a complex relationship with her creators, Elsa and Clive, Dren ultimately attacks Elsa in a moment of rage and jealousy. During this confrontation, Dren demonstrates her physical strength and primal instincts, leading to a violent encounter that significantly impacts Elsa. This scene highlights the themes of control, creation, and the consequences of playing with nature.

In the movie "Splice," Elsa, played by Sarah Polley, becomes pregnant with the hybrid creature named Dren, whom she and her colleague Clive (Adrien Brody) created through genetic experimentation. The pregnancy occurs after Dren, who is a product of human and animal DNA splicing, undergoes a rapid growth phase and exhibits characteristics that lead to an unexpected and complicated bond with Elsa. The film explores themes of creation, ethics in science, and the consequences of playing with nature.

As of now, there is no official sequel to the movie "Splice," which was released in 2009. While "Splice" received a mix of reviews and garnered a cult following, a sequel has not been produced or announced. Director Vincenzo Natali and the film's producers have not indicated any plans for a "Splice 2." The film remains a standalone piece exploring themes of genetic manipulation and ethical boundaries.

No, "Splice" is not based on a true story. The film, released in 2009, is a science fiction horror movie that explores themes of genetic engineering and bioethics. It follows two scientists who create a hybrid creature by splicing human and animal DNA. While the scientific concepts of genetic manipulation and cloning are rooted in real science, the specific events and characters in "Splice" are fictional and serve to explore the moral dilemmas and consequences of such experiments.