"Scrubs" was originally aired on NBC from 2001 to 2008. The network canceled the show primarily due to declining ratings, particularly in its later seasons. Despite its loyal fan base and critical acclaim, viewership dropped as the show went through various changes in cast and storylines. After its cancellation by NBC, "Scrubs" continued for a ninth season on ABC, which had a different format and focus but ultimately failed to attract significant audiences, leading to the show's final cancellation.

In the context of the TV show "Scrubs," "scrubs" refer to the medical uniforms worn by hospital staff, particularly doctors and nurses. The term also colloquially describes inexperienced medical interns or residents who are still in training, navigating their early careers in a hospital. The series humorously explores their challenges and growth, focusing on the personal and professional lives of these characters, particularly Dr. John "J.D." Dorian and his friends at Sacred Heart Hospital.

Zach Braff, who portrayed J.D. in "Scrubs," left the show after its eighth season primarily to pursue other projects and opportunities in his career. He felt that the series had reached a natural conclusion for his character, and he wanted to explore new creative endeavors, including directing and acting in films. Although he returned for a few guest appearances in the ninth season, his departure marked a significant shift in the show's dynamic as it transitioned to a more ensemble format.

"Scrubs" is often regarded as one of the most medically accurate shows due to its collaboration with real medical professionals, including doctors and surgical consultants, who provided insights into hospital procedures, medical terminology, and patient care. The show's creator, Bill Lawrence, emphasized realism in the portrayal of the medical field while balancing humor and emotional storytelling. The series accurately depicts the challenges and ethical dilemmas faced by healthcare workers, making it both entertaining and educational about the realities of hospital life.