An influential American film director, she emerged in the 1980s with her debut feature "Smithereens," becoming the first American independent film to compete at Cannes. Known for blending comedy and drama, she gained further acclaim with "Desperately Seeking Susan," a film that captured the zeitgeist of New York City's vibrant scene. Her works often highlight strong, quirky female characters. She has continued to work in both film and television, maintaining a unique voice in the industry.