An accomplished American actress, she gained recognition for her role as Lisa Miller on the sitcom "NewsRadio" in the 1990s. She further established her career with her portrayal of Dr. Abby Lockhart on the long-running medical drama "ER," earning critical acclaim and a devoted fan base. Known for her versatility, she has appeared in both film and television, including roles in "The Affair" and "Insomnia." Her work has garnered several award nominations, including a Golden Globe win.